Run the check
Record game frame time and mouse setting in the same scene.
Change only the mouse report setting and repeat several comparable runs.
Restore the original setting to check whether the pattern returns.
Read the result
A reversible change in frame spikes is stronger than one smooth run.
Limits and next step
Browser event-rate estimates cannot prove USB interrupt or game-engine causation.
Repeat the check after changing one setting or connection. Keep a record of what changed before deciding whether the device needs service.